Urinary Tract Infections

By Matthew Craig Park, OMS III, Osteopathic Physician Candidate 2016, and
Courtney Mizuhara-Cheng, D.O., M.S.H.S.

Bacterial infections of the female urinary tract are a frequent clinical problem.  In general, women experience urinary tract infections (UTI) much more than males due to their shorter urethra, which drastically reduces the distance bacteria must travel to access the bladder.  Though teenagers and young adults are often the population associated with such infections due to the onset of sexual activity, increasing age is actually one of the more important risk factors for the onset of UTI, since incontinence, or a lack of bowel or bladder control, and a decline in kidney function are diseases more associated with adulthood.  Fall and winter also seem to be the months where most UTI’s are reported; therefore, it’s important to highlight just what a UTI is, what the risk factors are, and how they can be managed in order to prevent their occurrence.

What is a Urinary Tract Infection (UTI)?  UTI’s are an infection in any part of the urinary system—the kidneys, ureters, bladder, and urethra.  Most infections involve the lower urinary tract, including the bladder and urethra. 

What causes a UTI?  UTI’s often occur when bacteria enter the urinary tract through the urethra and begin multiplying in the bladder.  Normal urine is sterile and contains fluid (mostly water), salts, and waste products, and is free of bacteria, viruses, or fungi.  Infections occur when microorganisms, usually bacteria from the gastrointestinal tract, enter via the opening of the urethra, the hollow tube that carries urine from the bladder to exit the body.  There are 2 main types of UTI: 

1.      Infection of the bladder, or cystitis: The type of UTI is usually secondary to E. coli, a type of bacteria found in the gastrointestinal (GI) tract of normal, healthy people.  The seeding of E coli into the urethra is often due to sexual intercourse, but patients do not need to be sexually active to develop this type of infection. 
2.      Infection of the urethra, or urethritis: This type of UTI occurs when GI bacteria spread from the anus to the urethra.  This is another example of why women are victims of UTI more commonly than men—the close proximity of the female urethra to the anus makes this type of infection much more likely.

Risk
Description
Being female
Shorter urethra means easier access for bacteria
Sexual activity
Accidental seeding of E coli into the urinary tract
Certain types of birth control
Women who use diaphragms carry a higher risk
Completing menopause
Lack of estrogen can cause changes to the urinary tract that make it more vulnerable to infection
Any blockages to the urinary system
Kidney stones or enlarged prostate can trap the urine in the bladder and increase infection risk
Antibiotic Use
This could kill off the beneficial microorganisms of the urinary system that could predispose a patient to colonization from a harmful strain

How do I know if I have a UTI?  UTI’s do not always carry signs and symptoms, but if you are symptomatic, the most common complaints include: a strong, persistent urge to urinate (urinary urgency), a burning sensation when urinating, passing frequent, small amounts of urine (urinary frequency), cloudy urine, strong-smelling urine, pelvic pain in women or rectal pain in men, and urine that may appear red, bright pink, or “cola colored”—a sign of blood in the urine.   If someone has a UTI that goes undiagnosed for an extended period of time, the infection can spread to the kidney and cause a kidney infection, or pyelonephritis.  Pyelonephritis is a much more serious infection that carries more broad signs and symptoms, including a high fever, shaking and chills, nausea, vomiting, and upper back or side (flank) pain.

Part of the urinary tract affected
Signs and Symptoms
Kidney (acute pyelonephritis)
           Upper back or side (flank) pain
High fever
Nausea or vomiting
Shaking or chills
Bladder (cystitis)
           Pelvic pressure
Lower abdomen pain
Frequent urination
Blood in urine
Urethra (urethritis)
          Burning with urination
How is a UTI treated?  Uncomplicated UTI’s are usually easily treated with antibiotics, as they are mostly bacterial in origin.  The type of antibiotic prescribed varies depending on the type of infection, but, usually, some commonly prescribed treatments include: Trimethoprim-sulfamethoxazole (Bactrim, Septra), Amoxicillin, Nitrofurantoin (often indicated in pregnant patients), and Ampicillin, among others.  In addition, proper hydration is often required to help clear the bacteria from the urinary tract.  In general, symptoms clear within a few days of treatment.  Doctors may also prescribe a pain medication (analgesic) to help numb the bladder to relive symptoms of burning with urination.   It should also be noted that a common side effect of urinary tract analgesics is discolored urine, often turning urine orange or red.

What if my symptoms get worse?  Often, women who have had a UTI before can self diagnose their subsequent infections based on similarity of symptoms and expect equal bacterial clearance and symptoms resolution with similar treatments.  However, if not promptly treated, UTI can have serious consequences, which may include: recurrent infections, permanent kidney damage from acute or chronic kidney infection, increased risk of women delivering low birth weight or premature infants.  It is important that if you feel as though you have an infection, please seek medical help as soon as you can.

What can I expect when I see my doctor?  Your doctor will likely inquire about the frequency of the infection and what has worked in the past and any side effects experienced from certain medications.  They will also need a urine sample in order to examine for typical infection markers of UTI.

Connect with your Urinary System 

What is the urinary system?  As stated before, the urinary system is the system where urine is made and evacuated in the body—urine is initially produced in the kidneys, flows out from the kidneys in the ureters and into the bladder, before being expelled from the body through the urethra. 

How does E coli cause UTI?  E coli are a normal inhabitant of the human gastrointestinal tract.  Following accidental colonization into the urethra, small appendages on the bacteria called fimbria allow for the organism to attach to the bladder surface.  Once attached, the bacteria secrete chemicals to allow for penetration into the cells of the bladder.  Inside these cells, the bacteria continue to replicate.  Once a sufficient bacterial colonization occurs and if no treatment has been administered, the bacteria can ascend the ureter towards the kidney.  Urine tests showing + nitrites or leukocyte esterase are highly suggestive of UTI.  Nitrites are positive due to bacterial reduction of endogenous human substances called nitrates into nitrites.   Leukocyte esterase is an enzyme secreted from the natural human immune system white blood cells that aids in inflammation and migration of our body’s immune cells toward the site of infection to help clear the unwanted bacteria.

How does the body work as a unit?  The urinary system is responsible for clearing the normal waste products produced by the human body.  If, for any reason, this system is blocked or cannot function properly, these wastes build up and can have drastic effects on every organ system. 

Harmonize with Body

What is some lifestyle advice?  First and foremost, proper hydration is key.  It is always important to drink enough fluids, especially water, to help dilute urine and flush out any bacteria that may be present incidentally.  Additionally, all patients, especially women, must implement proper wiping techniques after using the restroom—wiping front to back helps prevent bacteria from the anal region from being accidentally implanted at the urethra.  Additionally, emptying your bladder soon after intercourse can also help prevent this improper seeding.  Finally, avoiding potentially irritating feminine products like deodorant sprays or douching can help prevent undue irritation to the urethra.

What is some nutritional advice?  Although not scientifically proven, cranberry juice may have infection-fighting properties and drinking it daily may help prevent UTI.  Some studies have shown that the greatest effect of cranberry juice seems to be in women who have frequent UTI’s.  There are no known studies that show how much or how often cranberry juice should be consumed.

Integrate Complimentary Alternative Medicine

What can be expected during an osteopathic manipulative treatment?  Your osteopathic physician will release strain patterns preventing proper urinary elimination by allowing the nerve and blood supply to the bladder, kidneys and ureter to be unrestrained. The lumbar, sacrum, pelvis and abdomen will be restored to its proper alignment without restriction.   During an infection, lymphatic drainage of the pelvic region can be employed as needed.  Ganglion contractions blocking lymphatic drainage called "Chapman points" can be treated during an infection using firm pressure in a circular fashion until the tender mass disappears.
What are some homeopathic advice?  Depending on the presentation of the infection, certain homeopathic medications are typically useful in decreasing the duration and intensity of the infection.  If you are experiencing sharp burning before, during, and after urination with frequent but scant urination, take five pellets of Cantharis alternating with Mercurius Corrosivus between meals.